Selective C-H Olefination of Indolines (C5) and Tetrahydroquinolines (C6) by Pd/S,O-Ligand Catalysis
| Authors |
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| Publication date | 06-12-2019 |
| Journal | Organic Letters |
| Volume | Issue number | 21 | 23 |
| Pages (from-to) | 9339-9342 |
| Number of pages | 4 |
| Organisations |
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| Abstract | Herein, we report a highly selective C-H olefination of directing-group-free indolines (C5) and tetrahydroquinolines (C6) by Pd/S,O-ligand catalysis. In the presence of the S,O-ligand, a wide range of challenging indolines, tetrahydroquinolines, and olefins was efficiently olefinated under mild reaction conditions. The synthetic potential of this methodology was demonstrated by the efficient olefination of several indoline-based natural products. |
| Document type | Article |
| Note | With supplementary file |
| Language | English |
| Published at | https://doi.org/10.1021/acs.orglett.9b03505 |
| Downloads |
acs.orglett.9b03505
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