Initiation and regulation of specific immune responses by keratinocytes and dendritic cells. Role of cytokines and chemokines linking innate and specific immunity

Authors	M.C.G.M. Lebre
Supervisors	M.L. Kapsenberg J.D. Bos
Cosupervisors	E.C. de Jong
Award date	21-05-2003
Number of pages	168
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Immunologie
Language	English
Downloads	Thesis Cover STELLINGEN Titlepage Abbreviations Contents CHAPTER 1 General Introduction CHAPTER 2 The role of Toll-like receptors in chemokine and cytokine production by human keratinocytes in response to different pathogen-associated molecular patterns CHAPTER 3 Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a type-1 polarized phenotype in dendritic cells. Role of keratinocyte-derived TNF- , type I IFNs and IL-18 CHAPTER 4 Differential expression of inflammatory chemokines by Th1-and Th2-cell promoting dendritic cells (DC1 and DC2). A role for different mature DC populations in attracting appropriate effector cells to peripheral sites of inflammation CHAPTER 5 BDCA3hi dendritic cells: a novel subset with distinct phenotypical characteristics CHAPTER 6 Reduced production of bioactive IL-12 and IFN- by peripheral blood dendritic cells in atopic dermatitis patients CHAPTER 7 General Discussion Summary Nederlandse samenvatting Sumário Acknowledgements Curriculum vitae Publications Color Figures Cover
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