Host-pathogen interactions during melioidosis. When the bug meets its host

Melioidosis, caused by the bacterium Burkholderia pseudomallei, is an important cause of community-acquired sepsis and related death in Southeast Asia and Northern Australia. After recognition of the invaded bacterium the host’s immune system elicits a powerful immune response, essential to eliminate the microorganism. However, an overwhelming systemic inflammatory response can lead to detrimental tissue damage and death. Keeping the balance between pro- and anti-inflammatory processes is therefore crucial for survival of the host.
This thesis presents an overview of experimental studies on the role of innate immune receptors and specific proteins during melioidosis.